Natural Products: Back to the Future in Drug Discovery
نویسندگان
چکیده
منابع مشابه
Natural Products: Back to the Future in Drug Discovery
Nature offers an endless pool of unique molecular frameworks with desirable drug-like properties, rendering them ideal starting points for the development of pharmaceuticals [1]. In fact, the history of natural products (NPs) in drug discovery has been extraordinarily successful over the past century, highlighted by prominent examples as the antitumor agents taxol, vinblastine or doxorubicin, t...
متن کاملNatural products in drug discovery.
Natural products have been the single most productive source of leads for the development of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer agents and anti-infectives. Application of molecular biological techniques is increasing the availability of novel compounds that can be conveniently produced in bacteria or yeasts, and combinatorial chemistry approa...
متن کاملNatural products and drug discovery
The medicinal use of natural products—compounds that are derived from natural sources such as plants, animals or micro-organisms—precedes recorded human history probably by thousands of years. Palaeoanthropological studies at the cave site of Shanidar, located in the Zagros Mountains of Kurdistan in Iraq, have suggested that more than 60,000 years ago, Neanderthals might have been aware of the ...
متن کاملMarine natural products in drug discovery
Marine organisms comprise approximately a half of the total biodiversity, thus offering a vast source to discover useful therapeutics. In recent years, a significant number of novel metabolites with potent pharmacological properties have been discovered from the marine organisms. Although, there are only few marine derived products currently in the market, several marine natural products are no...
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ژورنال
عنوان ژورنال: Biochemistry & Pharmacology: Open Access
سال: 2012
ISSN: 2167-0501
DOI: 10.4172/2167-0501.1000e112